Short Title:Drug Synthesis
Full Title:Drug Synthesis
Language of Instruction:English
Module Code:DRUG H4002
 
Credits: 5
Field of Study:Science
Module Delivered in 1 programme(s)
Reviewed By:JOHN BEHAN
Module Author:BRIAN MURRAY
Module Description:Having completed this module the students will have: Advanced knowledge of the synthesis and reactivity of wide-range of aromatic heterocycles and cyclic structures, especially those with relevance to Pharmaceutical drugs; the mechanisms involved in these syntheses will be studied in detail; studies of natural products and analogues, will be undertaken to demonstrate this very important source of pharmaceutical drugs. Phosphorus and sulfur chemistry, as well as palladium catalysed coupling reactions (Heck, Still, Suzuki, etc.) in drug synthesis; Design methods for multistep routes to important pharmaceuticals and privileged structures, emphasising cyclic compounds; Spectroscopic and other methods of structural elucidation to a level allowing identification of unknown drug and drug intermediate substances, including treating a product of a synthesis as “unknown” until the structure is proven; Spectroscopic methods of establishing purity of products of such syntheses.
Learning Outcomes
On successful completion of this module the learner will be able to:
LO1 Describe the synthesis of important aromatic heterocycles of relevance to pharmaceuticals, including the mechanisms of their formation.
LO2 Design and develop multi-step synthetic routes to heterocyclic and natural product analogues, especially using cyclisation reactions.
LO3 Discuss the use of sulfur and phosphorus reagents, and palladium catalysed coupling reactions in drug synthesis, including mechanisms.
LO4 Transform a target molecule into simple starting materials, then choose the correct reagents for the synthetic route, including drawing reaction mechanisms.
LO5 Identify the spectroscopic changes in going from reactants to products in drug syntheses of the type & level carried out in the “Drug Synthesis” experiments of Integrated Laboratory Techniques.
LO6 Use appropriate deductive logic to identify an unknown drug or drug intermediate substance, given spectroscopic (NMR, IR, etc.) and other data (molecular formula, solubility & other physical properties, results of “wet” tests).
 

Module Content & Assessment

Course Work
Assessment Type Assessment Description Outcome addressed % of total Assessment Date
Continuous Assessment n/a 1,2,3,4,5,6 30.00 n/a
End of Module Formal Examination
Assessment Type Assessment Description Outcome addressed % of total Assessment Date
Formal Exam End-of-Semester Final Examination 1,2,3,4,5,6 70.00 End-of-Semester

TU Dublin – Tallaght Campus reserves the right to alter the nature and timings of assessment

 

Module Workload

Workload: Full Time
Workload Type Workload Description Hours Frequency Average Weekly Learner Workload
Lecture theory delivery; drug design problem solving; solving unknown chemical structures from spectroscopic information 4.00 Every Week 4.00
Independent Learning problem solving; reading the literature around the course content (books and journal papers, etc,); CA and exam preparation 4.00 Every Week 4.00
Total Weekly Learner Workload 8.00
Total Weekly Contact Hours 4.00
This module has no Part Time workload.
 

Module Resources

Required Book Resources
  • Clayden, Greeves, Warren and Wothers 2012, Organic Chemistry, 2nd Ed Ed., Oxford University Press [ISBN: 978-019927029]
  • S. Warren, P. Wyatt 2008, Organic Chemistry: The Disconnection Approach, 2nd Ed Ed., Wiley-Interscience [ISBN: 978-047071236]
  • Davies 1994, Aromatic Heterocyclic Chemistry, Oxford Univ. Press
  • S. Warren, P. Wyatt 2007, Organic Synthesis: Strategy and Control, Wiley-Interscience [ISBN: 978-047192963]
  • R. M. Silverstein, F. X. Webster, D. J. Kiemle, & D. L. Bryce 2013, Spectrometric Identification of Organic Compounds, 8th Ed Ed., Wiley-Interscience [ISBN: 978-0-470-616]
Recommended Book Resources
  • Smith 2013, March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, 7th Ed Ed., Wiley-Interscience [ISBN: 978-047046259]
  • Joule, Mills, & Smith 2010, Heterocyclic Chemistry, 5th Ed. Ed., Wiley-Interscience [ISBN: 978-140513300]
This module does not have any article/paper resources
This module does not have any other resources
 

Module Delivered in

Programme Code Programme Semester Delivery
TA_SPHAR_B Bachelor of Science (Honours) in Pharmaceutical Science 7 Mandatory